Urology · Enlarged prostate · HoLEP · Aquablation

Donald A. Neff

MD, FACS

Firefighter · Paramedic · Surgeon Kansas City, Kansas
01

In their words

What patients say

Kindness first.

Patients describe compassion at the hardest moments — including the day they first heard a difficult diagnosis.

Patients feel heard.

Unhurried visits, plain-language explanations, and questions answered until there are none left.

Lifelong relationships.

Patients describe trust strong enough to follow him between health systems for surgery, and a care team that makes hard visits easier.

02

About

The story

Show up.
Listen.
Act.

Dr. Donald A. Neff, MD, FACS – Associate Professor of Urology at the University of Kansas Medical Center

Dr. Neff’s first patients weren’t in a clinic. As a firefighter–paramedic in Janesville, Wisconsin, he learned medicine where it is most human: at the kitchen table, on the roadside, in the moments when showing up is everything. That foundation — hands-on, unhurried, personal — still shapes how he practices today.

He earned his biology degree at the University of Wisconsin–Whitewater, his medical degree at the Medical College of Wisconsin, and completed his urology residency at the Medical College of Wisconsin Affiliated Hospitals. Today he is an Associate Professor of Urology at The University of Kansas Medical Center and a Fellow of the American College of Surgeons.

He is nationally recognized for anatomic enucleation of the prostate (HoLEP / AEEP) and Aquablation therapy — and as a national instructor, he trains the surgeons who bring these techniques to patients across the United States.

03

Clinical focus

Expertise

i

HoLEP — Holmium laser enucleation

The gold-standard, size-independent procedure for enlarged prostate: the entire obstructing tissue is removed with minimal blood loss and rapid recovery.

ii

Aquablation therapy

Robotic, heat-free waterjet ablation that tailors tissue removal to your anatomy — designed to preserve ejaculatory and sexual function.

iii

Minimally invasive options

Including UroLift® and Optilume®, selected for the right patient to balance symptom relief with recovery time.

iv

Medical management

Evidence-based medication plans that relieve urinary symptoms while fitting your overall health — surgery only when it serves you.

v

Stone & trauma care

Advanced endoscopic and minimally invasive techniques for kidney stones and urologic injuries.

04

Beyond the operating room

Teaching & research

National HoLEP instructor

Training practicing surgeons across the United States in holmium laser enucleation of the prostate.

Resident Teaching Awards

Recognized by University of Kansas urology residents in 2018 and 2024.

AI decision support

Principal investigator on AI-driven tools that help patients and clinicians personalize BPH care.

National speaker

Invited faculty at national BPH and endourology meetings.

05

Building what’s next

AI in urologic practice

Dr. Neff leads one of the first department-level AI adoption programs in academic urology. The goal is practical: tools that make surgical training sharper, research faster, and patient education clearer, built and tested inside a working surgical practice rather than bought off a shelf.

OR Prep

An AI-powered case preparation platform used daily by University of Kansas urology residents. It turns a single-screen case entry into a structured pre-operative briefing in under a minute, so residents walk into the operating room prepared to learn, not scrambling to catch up. Post-case debriefs feed an active research program on surgical education.

UroIndex

A literature search and retrieval tool built for how surgeons actually ask questions. It searches the urologic literature and pulls full-text evidence directly, cutting the distance between a clinical question and a sourced answer.

Prostate Anatomy Visualizer

An interactive 3D anatomy application for patient education and resident teaching, built around the anatomic planes of prostate enucleation. Patients see exactly what their procedure does; trainees see the anatomy the way the surgeon does.

Research & leadership

Principal investigator on AI-driven decision support for personalizing BPH care. Dr. Neff writes and speaks on the responsible adoption of AI in surgical practice, with a focus on tools that earn clinician trust through transparency and measured evidence.

Every tool above was designed, built, and iterated by Dr. Neff and his team, in clinical use today at an academic medical center.

06

Scholarship

Selected publications

01 Flexible and navigable suction ureteral access sheath’s impact on ureteroscope deflection. 02 Silent satisfaction and improved laser ergonomics with TFL: a prospective randomized controlled trial comparing SuperPulse thulium fiber laser versus high-power Ho:YAG with MOSES for flexible ureteroscopy. 03 Vacuum-assisted renal sheath clears 1 cm³ of stone faster than non-suction sheath in mini-percutaneous nephrolithotomy. 04 Intrarenal pressure and flow rate profile using LithoVue™ Elite: impact of different irrigation systems and working channel instruments. 05 Holmium:YAG laser with MOSES technology is more efficient than thulium fibre laser in supine mini-percutaneous nephrolithotomy.
Book chapter in Conn’s Current Therapy 2025 Complete bibliography on PubMed →
07

Global impact

“Quality urologic care should transcend borders.”

For more than a decade, Dr. Neff has returned to Honduras each year — performing life-changing surgery and training the local physicians who carry the work forward long after the mission ends.

08

Qualifications

Credentials & honors

Education & training

  • BS, Biology — University of Wisconsin–Whitewater
  • MD — Medical College of Wisconsin
  • Urology residency — Medical College of Wisconsin Affiliated Hospitals

Certification & licensure

  • Diplomate, American Board of Urology
  • Licensed in Kansas, Missouri & Wisconsin

Memberships & honors

  • Fellow, American College of Surgeons
  • Member, American Urological Association
  • Alpha Omega Alpha Honor Medical Society
  • Magna cum laude, UW–Whitewater
  • KU Resident Teaching Awards — 2018, 2024